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STRATEGIES TO SUPPORT THE COVID-19 RESPONSE IN LMICs - Shared screen with speaker view
Hayet Abbassi
21:36
Several tests are getting FDA approval without any proof of efficacy. How can we figure out what test to use?
Hopkins CGH
22:20
Thanks for joining, everyone! Please feel free to ask your questions in the chat box and we will address them at the end of the presentation
Chandrakant Ruparelia
24:25
How to know about the validity and reliability of rapid test given that it may perform differently at different prevalence?
Yoko Shimada
24:35
What happened to the test developed by Stanford?
Hayet Abbassi
25:22
What was the issue with the original CDC test?
Chandrakant Ruparelia
26:57
are there recommendation on minimum number of tests that need to be performed per 1000 population to diagnose most cases?
Charlotte Gaydos
30:27
Cepheid can run off a battery too
Dr. Gregora N. Salazar
30:28
1)What is the exact protocol for testing (step by step) ? Chest X-Ray, serology testing? and what other testing? 2) If a person test negative , should that person be tested again , let's say within 4 weeks? or do we wait for symptoms to chow up? 3) In the USA , why the COVID-19 is not free for all residents? Other countries are not charging for it. Thank you
Amanda Debes
31:21
How expensive are the cartridges for each of these modular cartridge based devices? The Xpert cartridge for TB is quite expensive
Hayet Abbassi
31:46
Are these Molecular rapid testing like Abbott ID naw test one sample at a time?
Hayet Abbassi
35:33
Don’t you think it is better to use more robust test with at least 96 well plates and get more accurate results for at least 80 samples at time better than 13 min multiplied by 80 with doubtful results?
CJ Reuland
38:25
In response to Yoko Shimada’s question about the Stanford test: their RTPCR test was later approved by the FDA and went into use on March 5th.
CJ Reuland
39:28
In response to Hayet Abbassi’s question on the original CDC test: it appears that as a result of manufacturing issues, there was contamination of some of the reagents in the test kits, resulting in false positives of negative controls.
Marius
39:46
how sensitive is the GeneChecker? takes 4 hours vs NP swab PCR TAT 24hrs, but apparently lower sensitivity, accepted by CE but not FDA...??
Hayet Abbassi
40:13
Several labs discover that the Abbott ID naw pause a risk for the user and misses the low and medium positive cases tested by other platforms. This means that this test is not sensitive enough. Missing positive patients is very risky. What are your suggestions?
Amanda Debes
42:57
What do you think about re-infection regardless of antibody determination? How would immunization certificates work when we do not yet know if they are immune?
Hayet Abbassi
46:32
will individuals who have positive serology NOT SHED virus in case of second infection?
Tapati Dutta
47:43
Will these slides and recording be shared with the participants?
Hayet Abbassi
47:49
What’s about patients who get infected who don’t produce antibodies, how we address them?
Bob Bollinger
48:22
Can you comment on the pipeline for antibody-dependent RDT antigen tests?
Fernando Gonzalez
48:58
I agree that we don’t know if a serological test shows the IGg and 6 months later we get a second wave we don’t know its usefulness but the fact that a person has IGg and survive would mean they should be able to fight the virus a second time.
Dr. Gregora N. Salazar
49:39
I would like to know about the people who do not produce antibodies. What do we do? Do we test again and what do we test?
Bhakti Hansoti
49:46
The recording and resources will be posted to our webpage later on today.
Yolanda PG
51:03
The recording and resources will be posted to our webpage later on today. Link?
Udit Mohan
51:21
In resource limited settings and situations like a pandemic, considering the asymptomatic cases, qualitative vs quantitative tests(with no drastic difference in test time), which one should be preferred, a few weeks into the pandemic?
Hopkins CGH
51:32
Thanks so much for joining, everyone. Please visit http://hopkinsglobalhealth.org later today for recording and resources
Molly Holshouser
51:35
Hi Yuka! Do you know what is known about the sensitivity of the self-swab (nasal) vs the NP swab?
Hopkins CGH
51:41
We will also send an email to all participants with the links.
Hayet Abbassi
52:07
How can we figure out about the performance of a given test?
Molly Holshouser
54:13
Also, here in NYC we have been getting strong warnings from the city health department about poor specificity of currently available serologic tests, namely a lot of cross-reactivity with other common coronaviruses. Can you speak to this?
Charlotte Gaydos
55:50
There are two recent publications of comparison of tests in J Clin Micro comparing many of the available tests.
Dr. Gregora N. Salazar
56:23
I had my sister in Atlanta, Ga and she was charged$5000 for testing, serology only. She remained at home for 14 days. There was not a follow up. Is there any advice or protocol for follow-up with patients with symptoms or +COVID-19?
Bhakti Hansoti
58:09
If you can send us links to publications , resources - we will add them to the resource page
Charlotte Gaydos
01:00:07
Contact tracing will be needed for sure
Charlotte Gaydos
01:03:07
We do this for diabetes too
Hayet Abbassi
01:03:49
In china, they tested fecal matter with PCR for patient with gastro enteric symptoms.. any consideration for this kind of testing?
Mary Fassnacht
01:04:41
Thank you so much. This presentation was great!
Rene Genadry
01:07:04
Thanks much. Great talk. Could you comment on herd immunity and testing
Kelsey Murt
01:07:09
Thank you so much for this presentation-- it was great!
Dave Thomas
01:07:40
It probably goes without saying but the performance of a test has to do with the job the test is being asked to do. For diagnosis, antibodies are horrible early which unfortunately is generally when you are asking the question of what is the diagnosis. For tests of immunity, we have almost no information. For ‘infectivity’ we are really in a dark place, assuming culture is the gold std but ???
Dr. Gregora N. Salazar
01:07:45
Thank you to the organizers and presenters. Very important information. I appreciate your time and help.
Charlotte Gaydos
01:09:21
Poison distribution can affect positivity at low levels of virus where the reproducibility varies
Hayet Abbassi
01:11:20
The virus infect several organs and tissues besides the respiratory tract. Several are not developing respiratory disease but other disorders like strokes, PE, kidney diseases…, don’t you think we should redefine this disease ?
Yoko Shimada
01:12:46
Could you comment on what Sweden’s case in terms of their approach based on herd immunity argument?
Edwin Lugazia
01:12:48
Is there a possibility of the virus hibernating in the body as the case of the Ebola virus?
Charlotte Gaydos
01:12:54
That is why we need contact tracing
Amanda Debes
01:12:58
Thank you so much! This has been the best call I’ve joined on COVID to date (I do love diagnostics). Truly appreciate you presenting and going through the questions so well
Abel Ntungi
01:13:39
Thank you very much for the well organized discussion
Holly Nelson
01:13:40
Thank you so very much! This has been very informative!!
Molly Holshouser
01:14:24
Thanks, Yuka! Keep up the good work!
Srikanth Tripathy
01:14:39
Which IgG antibody test is most reliable at present based on current results available?
Stephanie Sirna
01:14:44
thank you very much
Hayet Abbassi
01:14:53
Thank you
Dr. Navni Mehta
01:14:55
thankyou so much
Shanna Dell
01:15:02
Thank you so much!
Charlotte Gaydos
01:15:05
Kudos to Yuka Tom and CJ!
Simon Dembe Kasango
01:15:06
Thank you very much!!
Naomi Brioche
01:15:08
Thank you
Dr. Bhakti Sanghvi
01:15:08
thank you so much
Yolanda PG
01:15:09
Thanks so much
Chandrakant Ruparelia
01:15:32
thanks Tom, Yuka and CJ for this most informative presentation
Fernand TOE
01:15:37
Thank you very much. Great job!
Molly Holshouser
01:15:43
Thank you for this series too
Vijaya Srinivas
01:15:47
Thank you very much-Vijaya
Srikanth Tripathy
01:15:49
Thank you
Hayet Abbassi
01:15:49
Many thanks
Yoko Shimada
01:15:53
Thanks!
Dr. Gregora N. Salazar
01:15:54
Bye
Ariel Pradipta
01:15:55
thank youy
Dr. Gregora N. Salazar
01:15:58
Thanks
Amita Gupta
01:16:00
Wonderful
Monika Mann
01:16:01
thanks!
Ludhang Pradipta Rizki
01:16:08
thanks
Marulam Panggabean
01:16:41
thanks
Angela Mushavi
01:37:32
I cannot hear anything-maybe I joined late??