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EBTC December Symposium
Tuesday 14 December 2021 9am - 10:30am EST
In here to out there: the counterintuitive and fascinating challenge of standardizing toxicity assays

Toxicological research is often conducted according to highly uneven standards. Difficulties in comparing the methods used by individual studies often seriously limits our ability to draw firm conclusions from even quite large bodies of evidence.

EBTC's next symposium is about new developments in solving this problem, in particular the marrying of novel techniques in semantic technology to traditional but challenging assay ring-testing and development.

There will be presentations and a Q&A panel from three highly experienced researchers in this space.

Dr Anne Thessen (University of Colorado Anschutz) will introduce some of the more surprising issues around assay consistency, including recent research that suggests scientists cannot reliably distinguish between live and dead zebrafish embryos. She will then describe how semantic technology can help improve this situation - not only in terms of data interoperability, but in reliably performing tasks such as scoring images of larvae.

Dr Sebastian Hoffmann (EBTC) will present an overview of EBTC's recent systematic review of zebrafish embryotoxicity assays. He will show why standardization is becoming such an important issue, particularly in an age where studies are viewed collectively and evidence synthesis is increasingly central to toxicology and chemical risk assessment.

Dr Kristen Ryan (National Toxicology Program) will discuss how broader uptake of the use of zebrafish in toxicology screening is hampered by lack of harmonization in experimental protocols, data analysis, and reporting of research. The SEAZIT program has been launched to address this; Dr Ryan will present on the goals of the program and how it will achieve them.

Dec 14, 2021 09:00 AM in Eastern Time (US and Canada)

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